San Francisco 49ers vs Los Angeles Rams Prediction, Odds & Picks 10/3/2022

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The San Francisco 49ers will looking to reaction to a difficult loss in prime time with another appearance under the lights when they host the Los Angeles Rams on Monday Night Football as tiny home favorites at sportsbooks.The San Francisco 49ers lost to the Denver Broncos 11-10 in Week 3 Sunday Night Football while one and a half point favorites, thus staying winless away from home at 0-2.

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San Francisco 49ers vs Los Angeles Rams Odds And Line Movement

Bettors who have placed early wagers on the San Francisco 49ers are pushing the point spread up to as high as -2.5 at the best San Francisco betting sites. Also, the top Los Angeles gambling apps list the total at 42, which is six points from where it opened.

The UNDER is 7-0 in the home team’s previous seven games as favorites and 6-0 in their previous six overall, while the visitors have a 6-1 run below the total based on their past seven prime-time matches.This appears to be a defensive fight on all fronts.

Find the best Rams vs 49ers odds and lines at our recommended live betting sportsbooks to make your picks for the night.

Notes On The San Francisco 49ers

Despite a lackluster offense, the Rams’ defense managed to hold Kyler Murray and the Cardinals at bay, only allowing them 12 points in their 20-12 victory.

Murray passes 58 times and completes thirty-seven for over three hundred yards, but Los Angeles’ defense doesn’t let him score. He carries the ball twice for eight yards and was sacked 19 times. This huge dip in performance is nowhere near what happened the previous week against the Las Vegas Raiders.

After narrowly losing to Denver, Jimmy Garoppolo and the San Francisco team will attempt to step up their game against Los Angeles.

Notes On The Los Angeles Rams

Garoppolo will have played against one of the best NFL defenses, Broncos, and he’ll be fresh off his first start of the season with little time to recover.

With Trey Lance out for the season with an ankle injury, the 49ers will not have the same mobility from their quarterback position. Some may argue that they are getting a better passer at this point because he has more experience, but it is still a loss for them.

Garoppolo has beaten the Rams twice in the past season, so he’s seen success against them recently.

Consequently, he will probably have to move around and use his legs more this week, especially since left tackle Trent Williams has a high-ankle sprain and won’t be able to play for the next few games.

Can The San Francisco 49ers Cover The Pointspread?

The Los Angeles pass rush must be a difference-maker in order to cover the spread and win this game.Last season, Garoppolo made three rounds of mistakes, each resulting in an interception.

With Williams out of the picture, Garoppolo will be under more stress to make plays, and the Rams may take advantage and create more giveaways. If they can win the turnover battle, they’ll win this one.

Will The Los Angeles Rams Cover The Spread?

Kyle Shanahan, San Francisco’s head coach, has devised several plays to target Los Angeles’ weaknesses in their defense. Some of his most notable players include Deebo Samuel, who can play both wide receiver and running back roles.

Samuel has more rushes than receptions this season, but he’s only struck pay dirt once thus far. Deebo is such a powerful and unbreakable force, and he hasn’t yet burst onto the scene – this may end up being his coming-out party.

Prediction And Picks: San Francisco 49ers -2.5

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Author: Kenneth Peterson